Aging-induced type I interferon response at the choroid plexus negatively affects brain function | Zendy

Kuti Baruch | Zendy; Aleksandra Deczkowska | Zendy; Eyal David | Zendy; Joseph M. Castellano | Zendy; Omer Miller | Zendy; Alexander Kertser | Zendy; Tamara Berkutzki | Zendy; Zohar BarnettItzhaki | Zendy; Dana Bezalel | Zendy; Tony WyssCoray | Zendy; Ido Amit | Zendy; Michal Schwartz | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

Author(s) -

Kuti Baruch,

Aleksandra Deczkowska,

Eyal David,

Joseph M. Castellano,

Omer Miller,

Alexander Kertser,

Tamara Berkutzki,

Zohar BarnettItzhaki,

Dana Bezalel,

Tony WyssCoray,

Ido Amit,

Michal Schwartz

Publication year - 2014

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1252945

Subject(s) - choroid plexus , hippocampal formation , neurogenesis , cerebrospinal fluid , brain structure and function , cognitive decline , neuroscience , hippocampus , human brain , interferon , biology , cognition , central nervous system , medicine , immunology , dementia , disease

Excess signaling is bad for the aging brain Preventing antiviral-like responses may protect function in the aging brain. Baruchet al. monitored messenger RNA production in the choroid plexus, the interface between the blood and cerebrospinal fluid, in young and old mice (see the Perspective by Ransohoff). They detected an inflammatory response in older mice not present in the brain of young mice that was also seen in old aged human samples postmortem. Preventing signaling by the cytokine interferon-I, which normally helps in the antiviral response of the immune system, helped prevent the decrease in cognitive function seen in aged mice.Science , this issue p.89 ; see also p.36

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research