Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors | Zendy

Lida Katsimpardi | Zendy; Nadia K. Litterman | Zendy; Pamela A. Schein | Zendy; Christine Miller | Zendy; Francesco S. Loffredo | Zendy; Gregory R. Wojtkiewicz | Zendy; John W. Chen | Zendy; Richard Lee | Zendy; Amy J. Wagers | Zendy; Lee L. Rubin | Zendy

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Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

Author(s) -

Lida Katsimpardi,

Nadia K. Litterman,

Pamela A. Schein,

Christine Miller,

Francesco S. Loffredo,

Gregory R. Wojtkiewicz,

John W. Chen,

Richard Lee,

Amy J. Wagers,

Lee L. Rubin

Publication year - 2014

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1251141

Subject(s) - neurogenesis , neuroscience , neural stem cell , biology , neurovascular bundle , central nervous system , cognitive decline , stem cell , parabiosis , medicine , endocrinology , anatomy , microbiology and biotechnology , dementia , disease

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors. Age-related decline of neurogenesis and cognitive function is associated with reduced blood flow and decreased numbers of neural stem cells. Therefore, restoring the functionality of the niche should counteract some of the negative effects of aging. We show that factors found in young blood induce vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination in aging mice. Further, we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis. The identification of factors that slow the age-dependent deterioration of the neurogenic niche in mice may constitute the basis for new methods of treating age-related neurodegenerative and neurovascular diseases.

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