Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects | Zendy

Xiao-Dong Li | Zendy; Jiaxi Wu | Zendy; Daxing Gao | Zendy; Hua Wang | Zendy; Lijun Sun | Zendy; Zhijian J. Chen | Zendy

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Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

Author(s) -

Xiao-Dong Li,

Jiaxi Wu,

Daxing Gao,

Hua Wang,

Lijun Sun,

Zhijian J. Chen

Publication year - 2013

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1244040

Subject(s) - immune system , adjuvant , defence mechanisms , biology , signal transduction , immunology , microbiology and biotechnology , gene , genetics

Alarm Bells The presence of DNA in the cytosol of mammalian cells is a danger signal, indicating, for example, that a DNA-containing virus has infected the cell. This signal triggers an innate immune response, which involves the expression of type I interferons, and is critical for antiviral immunity and responses to DNA vaccines. Cyclic GMP-AMP synthase (cGAS) was recently identified as a sensor of cytosolic DNA.Liet al. (p.1390 , published online 29 August) now use knockout mice to provide genetic evidence that, in multiple cell types, cGAS is the primary DNA sensor required for the type I interferon response in vivo.

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