Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses | Zendy

Daxing Gao | Zendy; Jiaxi Wu | Zendy; You-Tong Wu | Zendy; Fenghe Du | Zendy; Chukwuemika Aroh | Zendy; Nan Yan | Zendy; Lijun Sun | Zendy; Zhijian J. Chen | Zendy

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Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

Author(s) -

Daxing Gao,

Jiaxi Wu,

You-Tong Wu,

Fenghe Du,

Chukwuemika Aroh,

Nan Yan,

Lijun Sun,

Zhijian J. Chen

Publication year - 2013

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1240933

Subject(s) - innate immune system , virology , biology , immunity , virus , immune system , human immunodeficiency virus (hiv) , activator (genetics) , immunology , gene , genetics

HIV Detection Is a (c)GAS Despite it being one of the most highly studied viruses, there are still many unknowns when it comes to HIV—including how it triggers the innate immune response.Gaoet al. (p.903 , published 8 August) now demonstrate that the DNA sensor cyclic GMP-AMP synthase (cGAS) detects HIV infection. Reverse-transcribed HIV DNA triggers cGAS and downstream activation of antiviral immunity. Detection of HIV, as well as the retroviruses simian immunodeficiency virus and murine leukemia virus, was abrogated in mouse and human cells deficient in cGAS—suggesting that cGAS may be a critical activator of innate immunity in response to retroviral infection.

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