A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes | Zendy

Susan Carpenter | Zendy; Daniel Aiello | Zendy; Maninjay Atianand | Zendy; Emiliano P. Ricci | Zendy; Pallavi Gandhi | Zendy; Lisa L. Hall | Zendy; Meg Byron | Zendy; Brian G. Monks | Zendy; Meabh Henry-Bezy | Zendy; Jeanne B. Lawrence | Zendy; Luke O'neill | Zendy; Melissa J. Moore | Zendy; Daniel R. Caffrey | Zendy; Katherine A. Fitzgerald | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

Author(s) -

Susan Carpenter,

Daniel Aiello,

Maninjay Atianand,

Emiliano P. Ricci,

Pallavi Gandhi,

Lisa L. Hall,

Meg Byron,

Brian G. Monks,

Meabh Henry-Bezy,

Jeanne B. Lawrence,

Luke O'neill,

Melissa J. Moore,

Daniel R. Caffrey,

Katherine A. Fitzgerald

Publication year - 2013

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1240925

Subject(s) - psychological repression , biology , gene , immune system , transcriptome , innate immune system , gene expression , rna , long non coding rna , regulation of gene expression , genetics , ribonucleoprotein , function (biology) , computational biology , microbiology and biotechnology

An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin-modifying factors. We have identified a long noncoding RNA (lncRNA) that acts as a key regulator of this inflammatory response. Pattern recognition receptors such as the Toll-like receptors induce the expression of numerous lncRNAs. One of these, lincRNA-Cox2, mediates both the activation and repression of distinct classes of immune genes. Transcriptional repression of target genes is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research