Sept4/ ARTS Regulates Stem Cell Apoptosis and Skin Regeneration | Zendy

Yaron Fuchs | Zendy; Samara Brown | Zendy; Travis Gorenc | Zendy; Joe Rodriguez | Zendy; Elaine Fuchs | Zendy; Hermann Steller | Zendy

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Sept4/ ARTS Regulates Stem Cell Apoptosis and Skin Regeneration

Author(s) -

Yaron Fuchs,

Samara Brown,

Travis Gorenc,

Joe Rodriguez,

Elaine Fuchs,

Hermann Steller

Publication year - 2013

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1233029

Subject(s) - xiap , regeneration (biology) , wound healing , stem cell , apoptosis , microbiology and biotechnology , hair follicle , skin repair , biology , cancer research , immunology , caspase , programmed cell death , genetics

Adult stem cells are essential for tissue homeostasis and wound repair. Their proliferative capacity must be tightly regulated to prevent the emergence of unwanted and potentially dangerous cells, such as cancer cells. We found that mice deficient for the proapoptotic Sept4/ARTS gene have elevated numbers of hair follicle stem cells (HFSCs) that are protected against apoptosis. Sept4/ARTS(-/-) mice display marked improvement in wound healing and regeneration of hair follicles. These phenotypes depend on HFSCs, as indicated by lineage tracing. Inactivation of XIAP, a direct target of ARTS, abrogated these phenotypes and impaired wound healing. Our results indicate that apoptosis plays an important role in regulating stem cell-dependent regeneration and suggest that this pathway may be a target for regenerative medicine.

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