Neurexin and Neuroligin Mediate Retrograde Synaptic Inhibition in C. elegans | Zendy

Zhitao Hu | Zendy; Sabrina L. Hom | Zendy; Tambudzai Kudze | Zendy; Xia-Jing Tong | Zendy; Seungwon Choi | Zendy; Gayane Aramuni | Zendy; Weiqi Zhang | Zendy; Joshua M. Kaplan | Zendy

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Neurexin and Neuroligin Mediate Retrograde Synaptic Inhibition in C. elegans

Author(s) -

Zhitao Hu,

Sabrina L. Hom,

Tambudzai Kudze,

Xia-Jing Tong,

Seungwon Choi,

Gayane Aramuni,

Weiqi Zhang,

Joshua M. Kaplan

Publication year - 2012

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1224896

Subject(s) - neuroligin , neurexin , neuroscience , neurotransmission , synaptic vesicle , microbiology and biotechnology , inhibitory postsynaptic potential , neurotransmitter , caenorhabditis elegans , schizophrenia (object oriented programming) , chemistry , biology , excitatory postsynaptic potential , gene , medicine , biochemistry , postsynaptic potential , central nervous system , psychiatry , vesicle , receptor , membrane

The synaptic adhesion molecules neurexin and neuroligin alter the development and function of synapses and are linked to autism in humans. Here, we found that Caenorhabditis elegans neurexin (NRX-1) and neuroligin (NLG-1) mediated a retrograde synaptic signal that inhibited neurotransmitter release at neuromuscular junctions. Retrograde signaling was induced in mutants lacking a muscle microRNA (miR-1) and was blocked in mutants lacking NLG-1 or NRX-1. Release was rapid and abbreviated when the retrograde signal was on, whereas release was slow and prolonged when retrograde signaling was blocked. The retrograde signal adjusted release kinetics by inhibiting exocytosis of synaptic vesicles (SVs) that are distal to the site of calcium entry. Inhibition of release was mediated by increased presynaptic levels of tomosyn, an inhibitor of SV fusion.

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