Landscape of Somatic Retrotransposition in Human Cancers | Zendy

Eunjung Lee | Zendy; Rebecca C. Iskow | Zendy; Lixing Yang | Zendy; Ömer Gökçümen | Zendy; Psalm Haseley | Zendy; Lovelace J. Luquette | Zendy; Jens G. Lohr | Zendy; Christopher Harris | Zendy; Jun Li | Zendy; Richard K. Wilson | Zendy; David A. Wheeler | Zendy; Richard A. Gibbs | Zendy; Raju Kucherlapati | Zendy; Charles Lee | Zendy; Peter V. Kharchenko | Zendy; Peter J. Park | Zendy

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Landscape of Somatic Retrotransposition in Human Cancers

Author(s) -

Eunjung Lee,

Rebecca C. Iskow,

Lixing Yang,

Ömer Gökçümen,

Psalm Haseley,

Lovelace J. Luquette,

Jens G. Lohr,

Christopher Harris,

Jun Li,

Richard K. Wilson,

David A. Wheeler,

Richard A. Gibbs,

Raju Kucherlapati,

Charles Lee,

Peter V. Kharchenko,

Peter J. Park

Publication year - 2012

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1222077

Subject(s) - somatic cell , transposable element , biology , genome , carcinogenesis , gene , genetics , human genome , retrotransposon , cancer , dna , computational biology

Movement in the Cancer Genome Transposable elements are genetic sequences that can replicate and move within the genome. The factors that make an element mobile are unknown but are generally considered rare in mammals.Leeet al. (p.967 , published online 28 June) analyzed five cancer types occurring among several individuals and found that three types of epithelial tumors exhibited high rates of element movement relative to brain and blood cancers. Furthermore, these somatically acquired, tumor-specific elements targeted genes in colorectal cancer that, when disrupted, impact gene expression and thus may be a factor in the progression of the cancers.

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