Lin28b Reprograms Adult Bone Marrow Hematopoietic Progenitors to Mediate Fetal-Like Lymphopoiesis | Zendy

Joan Yuan | Zendy; Cuong Nguyen | Zendy; Xiu-Huai Liu | Zendy; Chrysi Kanellopoulou | Zendy; Stefan A. Muljo | Zendy

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Lin28b Reprograms Adult Bone Marrow Hematopoietic Progenitors to Mediate Fetal-Like Lymphopoiesis

Author(s) -

Joan Yuan,

Cuong Nguyen,

Xiu-Huai Liu,

Chrysi Kanellopoulou,

Stefan A. Muljo

Publication year - 2012

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1216557

Subject(s) - lymphopoiesis , haematopoiesis , biology , bone marrow , stem cell , progenitor cell , microbiology and biotechnology , immunology , immune system

The immune system develops in waves during ontogeny; it is initially populated by cells generated from fetal hematopoietic stem cells (HSCs) and later by cells derived from adult HSCs. Remarkably, the genetic programs that control these two distinct stem cell fates remain poorly understood. We report that Lin28b is specifically expressed in mouse and human fetal liver and thymus, but not in adult bone marrow or thymus. We demonstrate that ectopic expression of Lin28 reprograms hematopoietic stem/progenitor cells (HSPCs) from adult bone marrow, which endows them with the ability to mediate multilineage reconstitution that resembles fetal lymphopoiesis, including increased development of B-1a, marginal zone B, gamma/delta (γδ) T cells, and natural killer T (NKT) cells.

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