Innate Response Activator B Cells Protect Against Microbial Sepsis | Zendy

Philipp J. Rauch | Zendy; Aleksey Chudnovskiy | Zendy; Clinton S. Robbins | Zendy; Georg F. Weber | Zendy; Martin Etzrodt | Zendy; Ingo Hilgendorf | Zendy; Elizabeth Tiglao | Zendy; JoseLuiz Figueiredo | Zendy; Yoshiko Iwamoto | Zendy; Igor Theurl | Zendy; Rostic Gorbatov | Zendy; Michael T. Waring | Zendy; Adam Chicoine | Zendy; Majd Mouded | Zendy; Mikaël J. Pittet | Zendy; Matthias Nahrendorf | Zendy; Ralph Weissleder | Zendy; Filip K. Świrski | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Innate Response Activator B Cells Protect Against Microbial Sepsis

Author(s) -

Philipp J. Rauch,

Aleksey Chudnovskiy,

Clinton S. Robbins,

Georg F. Weber,

Martin Etzrodt,

Ingo Hilgendorf,

Elizabeth Tiglao,

JoseLuiz Figueiredo,

Yoshiko Iwamoto,

Igor Theurl,

Rostic Gorbatov,

Michael T. Waring,

Adam Chicoine,

Majd Mouded,

Mikaël J. Pittet,

Matthias Nahrendorf,

Ralph Weissleder,

Filip K. Świrski

Publication year - 2012

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1215173

Subject(s) - innate immune system , biology , immunology , sepsis , effector , immunity , population , receptor , microbiology and biotechnology , immune system , medicine , genetics , environmental health

Recognition and clearance of a bacterial infection are a fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B cells are phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Specific deletion of IRA B cell activity impairs bacterial clearance, elicits a cytokine storm, and precipitates septic shock. These observations enrich our understanding of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new treatment avenues for infectious diseases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research