Widespread Genetic Switches and Toxicity Resistance Proteins for Fluoride | Zendy

Jenny L. Baker | Zendy; Narasimhan Sudarsan | Zendy; Zasha Weinberg | Zendy; Adam Roth | Zendy; Randy B Stockbridge | Zendy; Ronald R. Breaker | Zendy

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Widespread Genetic Switches and Toxicity Resistance Proteins for Fluoride

Author(s) -

Jenny L. Baker,

Narasimhan Sudarsan,

Zasha Weinberg,

Adam Roth,

Randy B Stockbridge,

Ronald R. Breaker

Publication year - 2011

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1215063

Subject(s) - riboswitch , fluoride , eukaryote , gene , rna , biology , genome , messenger rna , genetics , chemistry , computational biology , biochemistry , non coding rna , inorganic chemistry

Fluoride Riboswitch Riboswitches are found in prokaryote and eukaryote messenger RNAs (mRNAs), where they regulate expression of the linked mRNA through ligand binding and conformational change.Bakeret al. (p.233 , published online 22 December) analyzed the binding properties of the “crcB motif” found in the noncoding RNA at the 5′ end of a diverse collection of prokaryotic genes. AcrcB motif fromPseudomonas syringae was capable of selectively sensing the very small and highly charged fluoride ion. Some of thecrcB anderiC genes associated with the fluoride riboswitch showed evidence of being fluoride transporters. The bacteriumMethylobacterium extorquens DM4, which can use halogenated hydrocarbons as an energy source, was found to encode at least 10 fluoride riboswitches in its genome.

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