Comment on “Widespread RNA and DNA Sequence Differences in the Human Transcriptome” | Zendy

Joseph K. Pickrell | Zendy; Yoav Gilad | Zendy; Jonathan K. Pritchard | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Comment on “Widespread RNA and DNA Sequence Differences in the Human Transcriptome”

Author(s) -

Joseph K. Pickrell,

Yoav Gilad,

Jonathan K. Pritchard

Publication year - 2012

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1210484

Subject(s) - transcriptome , biology , genetics , dna sequencing , sequence (biology) , computational biology , gene , rna , human genome , dna , reference genome , genome , rna seq , gene expression

Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported more than 10,000 mismatches between messenger RNA and DNA sequences from the same individuals, which they attributed to previously unrecognized mechanisms of gene regulation. We found that at least 88% of these sequence mismatches can likely be explained by technical artifacts such as errors in mapping sequencing reads to a reference genome, sequencing errors, and genetic variation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research