Response to Comments on “Widespread RNA and DNA Sequence Differences in the Human Transcriptome” | Zendy

Mingyao Li | Zendy; Isabel X. Wang | Zendy; Vivian G. Cheung | Zendy

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Response to Comments on “Widespread RNA and DNA Sequence Differences in the Human Transcriptome”

Author(s) -

Mingyao Li,

Isabel X. Wang,

Vivian G. Cheung

Publication year - 2012

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1210419

Subject(s) - dna sequencing , sequence (biology) , transcriptome , biology , rna , genetics , dna , computational biology , human genome , genome , sequence analysis , gene , gene expression

Kleinman and Majewski, Pickrellet al ., and Linet al . suggest that mapping and sequencing errors and genetic variants led to false discovery of RNA-DNA sequence differences in our paper. We repeated our analysis using two different sequence alignment methods and carried out additional experiments including whole genome DNA sequencing. The results are consistent with our finding of widespread RNA-DNA sequence differences.

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