The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans | Zendy

Laurent AbiRached | Zendy; Matthew J. Jobin | Zendy; Subhash Kulkarni | Zendy; Alasdair McWhinnie | Zendy; Klara Dalva | Zendy; Loren Gragert | Zendy; Farbod Babrzadeh | Zendy; Baback Gharizadeh | Zendy; Ma Luo | Zendy; Francis A. Plummer | Zendy; Joshua Kimani | Zendy; Mary Carrington | Zendy; Derek Middleton | Zendy; Raja Rajalingam | Zendy; Meral Beksaç | Zendy; Steven G. E. Marsh | Zendy; Martin Maiers | Zendy; Lisbeth A. Guethlein | Zendy; Sofia Tavoularis | Zendy; AnnMargaret Little | Zendy; Richard E. Green | Zendy; Paul J. Norman | Zendy; Peter Parham | Zendy

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The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans

Author(s) -

Laurent AbiRached,

Matthew J. Jobin,

Subhash Kulkarni,

Alasdair McWhinnie,

Klara Dalva,

Loren Gragert,

Farbod Babrzadeh,

Baback Gharizadeh,

Ma Luo,

Francis A. Plummer,

Joshua Kimani,

Mary Carrington,

Derek Middleton,

Raja Rajalingam,

Meral Beksaç,

Steven G. E. Marsh,

Martin Maiers,

Lisbeth A. Guethlein,

Sofia Tavoularis,

AnnMargaret Little,

Richard E. Green,

Paul J. Norman,

Peter Parham

Publication year - 2011

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1209202

Subject(s) - biology , introgression , genotyping , allele , human leukocyte antigen , evolutionary biology , balancing selection , haplotype , genetics , genome , natural selection , human genome , selection (genetic algorithm) , gene , genotype , antigen , artificial intelligence , computer science

Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system components subject to strong balancing selection, shows how modern humans acquired the HLA-B*73 allele in west Asia through admixture with archaic humans called Denisovans, a likely sister group to the Neandertals. Virtual genotyping of Denisovan and Neandertal genomes identified archaic HLA haplotypes carrying functionally distinctive alleles that have introgressed into modern Eurasian and Oceanian populations. These alleles, of which several encode unique or strong ligands for natural killer cell receptors, now represent more than half the HLA alleles of modern Eurasians and also appear to have been later introduced into Africans. Thus, adaptive introgression of archaic alleles has significantly shaped modern human immune systems.

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