Open AccessUnfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response
Author(s) -
Brooke M. Gardner,
Peter Walter
Publication year - 2011
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.1209126
Subject(s) - endoplasmic reticulum , unfolded protein response , secretory protein , microbiology and biotechnology , protein folding , chemistry , secretory pathway , secretion , biochemistry , biology , golgi apparatus
A newly synthesized secretory protein quality control pathway is activated by direct binding of misfolded proteins to a sensor in the endoplasmic reticulum.
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