Targeted Genome Editing Across Species Using ZFNs and TALENs | Zendy

Andrew J. Wood | Zendy; TeWen Lo | Zendy; Bryan Zeitler | Zendy; Catherine S. Pickle | Zendy; Edward J. Ralston | Zendy; Andrew Lee | Zendy; Rainier Amora | Zendy; Jeffrey C. Miller | Zendy; Elo Leung | Zendy; Xiangdong Meng | Zendy; Lei Zhang | Zendy; Edward J. Rebar | Zendy; Philip D. Gregory | Zendy; Fyodor D. Urnov | Zendy; Barbara J Meyer | Zendy

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Targeted Genome Editing Across Species Using ZFNs and TALENs

Author(s) -

Andrew J. Wood,

TeWen Lo,

Bryan Zeitler,

Catherine S. Pickle,

Edward J. Ralston,

Andrew Lee,

Rainier Amora,

Jeffrey C. Miller,

Elo Leung,

Xiangdong Meng,

Lei Zhang,

Edward J. Rebar,

Philip D. Gregory,

Fyodor D. Urnov,

Barbara J Meyer

Publication year - 2011

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1207773

Subject(s) - transcription activator like effector nuclease , genome editing , genome , computational biology , zinc finger nuclease , biology , genetics , evolutionary biology , gene

Evolutionary studies necessary to dissect diverse biological processes have been limited by the lack of reverse genetic approaches in most organisms with sequenced genomes. We established a broadly applicable strategy using zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) for targeted disruption of endogenous genes and cis-acting regulatory elements in diverged nematode species.

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