Comparative Functional Genomics of the Fission Yeasts | Zendy

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Comparative Functional Genomics of the Fission Yeasts

Author(s) -

Nick Rhind,

Zehua Chen,

Moran Yassour,

Dawn Thompson,

Brian J. Haas,

Naomi Habib,

Ilan Wapinski,

Sushmita Roy,

Michael F. Lin,

David I. Heiman,

Sarah Young,

Kanji Furuya,

Yabin Guo,

Alison L. Pidoux,

Huei Mei Chen,

Barbara Robbertse,

Jonathan M. Goldberg,

Keita Aoki,

Elizabeth H. Bayne,

Aaron M. Berlin,

Christopher A. Desjardins,

Edward Dobbs,

Livio Dukaj,

Fan Lin,

Michael G. FitzGerald,

Courtney E. French,

Sharvari Gujja,

Klavs R. Hansen,

Daniel Keifenheim,

Joshua Z. Levin,

Rebecca A. Mosher,

Carolin A. Müller,

Jenna Pfiffner,

Margaret Priest,

Carsten Russ,

Agata Smialowska,

Peter Swoboda,

Sean M. Sykes,

Matthew Vaughn,

Sonya Vengrova,

Ryan J. Yoder,

Qiandong Zeng,

Robin C. Allshire,

David C. Baulcombe,

Bruce W. Birren,

William R. Brown,

Karl Ekwall,

Manolis Kellis,

Janet Leatherwood,

Henry L. Levin,

Hanah Margalit,

Rob Martienssen,

Conrad A. Nieduszynski,

Joseph W. Spatafora,

Nir Friedman,

Jacob Z. Dalgaard,

Peter Baumann,

Hironori Niki,

Aviv Regev,

Chad Nusbaum

Publication year - 2011

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1203357

Subject(s) - functional genomics , fission , genomics , computational biology , biology , chemistry , radiochemistry , genome , genetics , physics , gene , nuclear physics , neutron

The fission yeast clade--comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus--occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes identified a near extinction of transposons and the associated innovation of transposon-free centromeres. Expression analysis established that meiotic genes are subject to antisense transcription during vegetative growth, which suggests a mechanism for their tight regulation. In addition, trans-acting regulators control new genes within the context of expanded functional modules for meiosis and stress response. Differences in gene content and regulation also explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source. These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade.

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