α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro | Zendy

Jacqueline Burré | Zendy; Manu Sharma | Zendy; Theodoros Tsetsenis | Zendy; Vladimir L. Buchman | Zendy; Mark R. Etherton | Zendy; Thomas C. Südhof | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

Author(s) -

Jacqueline Burré,

Manu Sharma,

Theodoros Tsetsenis,

Vladimir L. Buchman,

Mark R. Etherton,

Thomas C. Südhof

Publication year - 2010

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1195227

Subject(s) - snare complex , neurodegeneration , microbiology and biotechnology , biology , chaperone (clinical) , syntaxin , synaptobrevin , synaptic vesicle , snap25 , membrane protein , vesicle , biochemistry , membrane , medicine , disease , pathology

α-Synuclein and Aging Transgenic α-synuclein can reverse the otherwise lethal neurodegeneration of cysteine string protein-α knockout mice via changes in SNARE proteins, which mediate synaptic vesicle release. Using experiments with purified recombinant proteins, triple αβγ-synuclein knockout mice, and studies of mouse aging,Burréet al. (p.1663 , published online 26 August) now demonstrate that α-synuclein directly interacts with the SNARE protein synaptobrevin and functions as a catalyst for SNARE-complex assembly. The role of synucleins is fully dispensable in young animals, but becomes essential late in life, which suggests that α-synuclein maintains normal synaptic function during aging.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research