The Fusogen EFF-1 Controls Sculpting of Mechanosensory Dendrites | Zendy

Meital OrenSuissa | Zendy; David H. Hall | Zendy; Millet Treinin | Zendy; Gidi Shemer | Zendy; Benjamin Podbilewicz | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Fusogen EFF-1 Controls Sculpting of Mechanosensory Dendrites

Author(s) -

Meital OrenSuissa,

David H. Hall,

Millet Treinin,

Gidi Shemer,

Benjamin Podbilewicz

Publication year - 2010

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1189095

Subject(s) - caenorhabditis elegans , neuroscience , neurite , biology , regeneration (biology) , microbiology and biotechnology , gene , genetics , in vitro

The mechanisms controlling the formation and maintenance of neuronal trees are poorly understood. We examined the dynamic development of two arborized mechanoreceptor neurons (PVDs) required for reception of strong mechanical stimuli in Caenorhabditis elegans. The PVDs elaborated dendritic trees comprising structural units we call "menorahs." We studied how the number, structure, and function of menorahs were maintained. EFF-1, an essential protein mediating cell fusion, acted autonomously in the PVDs to trim developing menorahs. eff-1 mutants displayed hyperbranched, disorganized menorahs. Overexpression of EFF-1 in the PVD reduced branching. Neuronal pruning appeared to involve EFF-1-dependent branch retraction and neurite-neurite autofusion. Thus, EFF-1 activities may act as a quality control mechanism during the sculpting of dendritic trees.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research