Comment on “Modafinil Shifts Human Locus Coeruleus to Low-Tonic, High-Phasic Activity During Functional MRI” and “Homeostatic Sleep Pressure and Responses to Sustained Attention in the Suprachiasmatic Area” | Zendy

Serguei V. Astafiev | Zendy; Abraham Z. Snyder | Zendy; Gordon L. Shulman | Zendy; Maurizio Corbetta | Zendy

Open Access

Comment on “Modafinil Shifts Human Locus Coeruleus to Low-Tonic, High-Phasic Activity During Functional MRI” and “Homeostatic Sleep Pressure and Responses to Sustained Attention in the Suprachiasmatic Area”

Author(s) -

Serguei V. Astafiev,

Abraham Z. Snyder,

Gordon L. Shulman,

Maurizio Corbetta

Publication year - 2010

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1177200

Subject(s) - locus coeruleus , tonic (physiology) , modafinil , neuroscience , functional magnetic resonance imaging , psychology , medicine , central nervous system , psychiatry

Minzenberg et al. (Reports, 12 December 2008, p. 1700) and Schmidt et al. (Reports, 24 April 2009, p. 516) reported blood oxygen level–dependent (BOLD) responses in the human locus coeruleus (LC). Here, we show that these LC responses do not correspond to the anatomical location of the LC and present cautionary data concerning the quality of BOLD signals measured from the LC using standard functional magnetic resonance imaging acquisition parameters.

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