Discovery of Swine as a Host for the Reston ebolavirus | Zendy

Roger W. Barrette | Zendy; Samia A. Metwally | Zendy; Jessica Rowland | Zendy; Lizhe Xu | Zendy; Sherif R. Zaki | Zendy; Stuart T. Nichol | Zendy; Pierre E. Rollin | Zendy; Jonathan S. Towner | Zendy; WunJu Shieh | Zendy; Brigid Batten | Zendy; Tara K. Sealy | Zendy; Consuelo Carrillo | Zendy; Karen Moran | Zendy; Alexa J. Bracht | Zendy; Gregory A. Mayr | Zendy; Magdalena Sirios-Cruz | Zendy; Davinio P. Catbagan | Zendy; Elizabeth A. Lautner | Zendy; Thomas G. Ksiazek | Zendy; W. R. White | Zendy; Michael T. McIntosh | Zendy

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Discovery of Swine as a Host for the Reston ebolavirus

Author(s) -

Roger W. Barrette,

Samia A. Metwally,

Jessica Rowland,

Lizhe Xu,

Sherif R. Zaki,

Stuart T. Nichol,

Pierre E. Rollin,

Jonathan S. Towner,

WunJu Shieh,

Brigid Batten,

Tara K. Sealy,

Consuelo Carrillo,

Karen Moran,

Alexa J. Bracht,

Gregory A. Mayr,

Magdalena Sirios-Cruz,

Davinio P. Catbagan,

Elizabeth A. Lautner,

Thomas G. Ksiazek,

W. R. White,

Michael T. McIntosh

Publication year - 2009

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1172705

Subject(s) - ebolavirus , marburg virus , ebola virus , virology , filoviridae , biology , outbreak , polyphyly , disease , host (biology) , virus , medicine , viral disease , genetics , phylogenetics , clade , paramyxoviridae , pathology , gene

Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.

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