Open AccessIn Vivo Analysis of Dendritic Cell Development and Homeostasis
Author(s) -
Kang Liu,
Gabriel D. Victora,
Tanja A. Schwickert,
Pierre Guermonprez,
Matthew M. Meredith,
Kai-Hui Yao,
Fei-Fan Chu,
Gwendalyn J. Randolph,
Alexander Y. Rudensky,
Michel C. Nussenzweig
Publication year - 2009
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.1170540
Subject(s) - microbiology and biotechnology , dendritic cell , bone marrow , spleen , precursor cell , monocyte , biology , lymphatic system , follicular dendritic cells , receptor tyrosine kinase , homeostasis , immunology , chemistry , t cell , cell , kinase , antigen presenting cell , immune system , biochemistry
Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates from the bone marrow to peripheral lymphoid organs are unknown. We show that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed precursors of cDCs (pre-cDCs). Pre-cDCs enter lymph nodes through and migrate along high endothelial venules and later disperse and integrate into the DC network. Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3.
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