Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast | Zendy

Assen Roguev | Zendy; Sourav Bandyopadhyay | Zendy; Martin Zofall | Zendy; Ke Zhang | Zendy; Tamás Fischer | Zendy; Sean R. Collins | Zendy; Hongjing Qu | Zendy; Michael Shales | Zendy; Han-Oh Park | Zendy; Jacqueline Hayles | Zendy; KwangLae Hoe | Zendy; Dong-Uk Kim | Zendy; Trey Ideker | Zendy; Shiv I. S. Grewal | Zendy; Jonathan S. Weissman | Zendy; Nevan J. Krogan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast

Author(s) -

Assen Roguev,

Sourav Bandyopadhyay,

Martin Zofall,

Ke Zhang,

Tamás Fischer,

Sean R. Collins,

Hongjing Qu,

Michael Shales,

Han-Oh Park,

Jacqueline Hayles,

KwangLae Hoe,

Dong-Uk Kim,

Trey Ideker,

Shiv I. S. Grewal,

Jonathan S. Weissman,

Nevan J. Krogan

Publication year - 2008

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1162609

Subject(s) - schizosaccharomyces pombe , epistasis , biology , genetics , schizosaccharomyces , gene , rna interference , computational biology , yeast , transcription (linguistics) , saccharomyces cerevisiae , rna , linguistics , philosophy

An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe, by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription regulation and DNA repair/replication. The E-MAP uncovered a previously unidentified component of the RNA interference (RNAi) machinery (rsh1) and linked the RNAi pathway to several other biological processes. Comparison of the S. pombe E-MAP to an analogous genetic map from the budding yeast revealed that, whereas negative interactions were conserved between genes involved in similar biological processes, positive interactions and overall genetic profiles between pairs of genes coding for physically associated proteins were even more conserved. Hence, conservation occurs at the level of the functional module (protein complex), but the genetic cross talk between modules can differ substantially.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research