Comment on "Differential Rescue of Light- and Food-Entrainable Circadian Rhythms" | Zendy

Ralph E. Mistlberger | Zendy; Shin Yamazaki | Zendy; Julie S. Pendergast | Zendy; Glenn J. Landry | Zendy; Toru Takumi | Zendy; Wataru Nakamura | Zendy

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Comment on "Differential Rescue of Light- and Food-Entrainable Circadian Rhythms"

Author(s) -

Ralph E. Mistlberger,

Shin Yamazaki,

Julie S. Pendergast,

Glenn J. Landry,

Toru Takumi,

Wataru Nakamura

Publication year - 2008

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1161284

Subject(s) - circadian rhythm , anticipation (artificial intelligence) , neuroscience , rhythm , biology , food intake , entrainment (biomusicology) , hypothalamus , chronobiology , psychology , audiology , endocrinology , medicine , computer science , artificial intelligence

Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1–/– mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions.

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