A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity | Zendy

Timothy M. Frayling | Zendy; Nicholas J. Timpson | Zendy; Michael N. Weedon | Zendy; Eleftheria Zeggini | Zendy; Rachel M. Freathy | Zendy; Cecilia M. Lindgren | Zendy; John R. B. Perry | Zendy; Katherine S. Elliott | Zendy; Hana Lango Allen | Zendy; Nigel W. Rayner | Zendy; Beverley M. Shields | Zendy; Lorna W. Harries | Zendy; Jeffrey C. Barrett | Zendy; Sian Ellard | Zendy; Christopher J. Groves | Zendy; Bridget Knight | Zendy; AnnMarie Patch | Zendy; Andy Ness | Zendy; Shah Ebrahim | Zendy; Debbie A. Lawlor | Zendy; Susan M. Ring | Zendy; Yoav BenShlomo | Zendy; MarjoRiitta Järvelin | Zendy; Ulla Sovio | Zendy; Amanda J. Bennett | Zendy; David Melzer | Zendy; Luigi Ferrucci | Zendy; Ruth J. F. Loos | Zendy; Inês Barroso | Zendy; Nicholas J. Wareham | Zendy; Fredrik Karpe | Zendy; Katharine R. Owen | Zendy; Lon R. Cardon | Zendy; Mark Walker | Zendy; G. A. Hitman | Zendy; Nicholette D. Palmer | Zendy; Alex S. F. Doney | Zendy; Andrew D. Morris | Zendy; George Davey Smith | Zendy; Andrew T. Hattersley | Zendy; Mark I. McCarthy | Zendy

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A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Author(s) -

Timothy M. Frayling,

Nicholas J. Timpson,

Michael N. Weedon,

Eleftheria Zeggini,

Rachel M. Freathy,

Cecilia M. Lindgren,

John R. B. Perry,

Katherine S. Elliott,

Hana Lango Allen,

Nigel W. Rayner,

Beverley M. Shields,

Lorna W. Harries,

Jeffrey C. Barrett,

Sian Ellard,

Christopher J. Groves,

Bridget Knight,

AnnMarie Patch,

Andy Ness,

Shah Ebrahim,

Debbie A. Lawlor,

Susan M. Ring,

Yoav BenShlomo,

MarjoRiitta Järvelin,

Ulla Sovio,

Amanda J. Bennett,

David Melzer,

Luigi Ferrucci,

Ruth J. F. Loos,

Inês Barroso,

Nicholas J. Wareham,

Fredrik Karpe,

Katharine R. Owen,

Lon R. Cardon,

Mark Walker,

G. A. Hitman,

Nicholette D. Palmer,

Alex S. F. Doney,

Andrew D. Morris,

George Davey Smith,

Andrew T. Hattersley,

Mark I. McCarthy

Publication year - 2007

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1141634

Subject(s) - obesity , body mass index , fto gene , odds ratio , allele , childhood obesity , diabetes mellitus , medicine , type 2 diabetes , polymorphism (computer science) , odds , genome wide association study , genetic predisposition , genetics , endocrinology , gene , biology , genotype , overweight , single nucleotide polymorphism , logistic regression

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.

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