Nuclear Activity of MLA Immune Receptors Links Isolate-Specific and Basal Disease-Resistance Responses | Zendy

QianHua Shen | Zendy; Yusuke Saijo | Zendy; Stefan Mauch | Zendy; Christoph Biskup | Zendy; Stéphane Bieri | Zendy; Beat Keller | Zendy; Hikaru Seki | Zendy; Bekir Ülker | Zendy; Imre E. Somssich | Zendy; Paul SchulzeLefert | Zendy

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Nuclear Activity of MLA Immune Receptors Links Isolate-Specific and Basal Disease-Resistance Responses

Author(s) -

QianHua Shen,

Yusuke Saijo,

Stefan Mauch,

Christoph Biskup,

Stéphane Bieri,

Beat Keller,

Hikaru Seki,

Bekir Ülker,

Imre E. Somssich,

Paul SchulzeLefert

Publication year - 2006

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1136372

Subject(s) - wrky protein domain , biology , effector , pathogen associated molecular pattern , repressor , pathogen , receptor , immune receptor , plant disease resistance , microbiology and biotechnology , immune system , powdery mildew , genetics , transcription factor , pattern recognition receptor , innate immune system , gene , botany , mutant , arabidopsis

Plant immune responses are triggered by pattern recognition receptors that detect conserved pathogen-associated molecular patterns (PAMPs) or by resistance (R) proteins recognizing isolate-specific pathogen effectors. We show that in barley, intracellular mildew A (MLA) R proteins function in the nucleus to confer resistance against the powdery mildew fungus. Recognition of the fungal avirulence A10 effector by MLA10 induces nuclear associations between receptor and WRKY transcription factors. The identified WRKY proteins act as repressors of PAMP-triggered basal defense. MLA appears to interfere with the WRKY repressor function, thereby de-repressing PAMP-triggered basal defense. Our findings reveal a mechanism by which these polymorphic immune receptors integrate distinct pathogen signals.

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