Common Kibra Alleles Are Associated with Human Memory Performance | Zendy

Andreas Papassotiropoulos | Zendy; Dietrich Stephan | Zendy; Matthew J. Huentelman | Zendy; Frédéric J. Hoerndli | Zendy; David W. Craig | Zendy; John V. Pearson | Zendy; KimDung Huynh | Zendy; Fabienne Brunner | Zendy; Jason J. Corneveaux | Zendy; David Osborne | Zendy; M. Axel Wollmer | Zendy; Amanda Aerni | Zendy; Daniel Coluccia | Zendy; Jürgen Hänggi | Zendy; Christian R.A. Mondadori | Zendy; Andreas Buchmann | Zendy; Eric M. Reiman | Zendy; Richard J. Caselli | Zendy; Katharina Henke | Zendy; Dominique J.F. de Quervain | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Common Kibra Alleles Are Associated with Human Memory Performance

Author(s) -

Andreas Papassotiropoulos,

Dietrich Stephan,

Matthew J. Huentelman,

Frédéric J. Hoerndli,

David W. Craig,

John V. Pearson,

KimDung Huynh,

Fabienne Brunner,

Jason J. Corneveaux,

David Osborne,

M. Axel Wollmer,

Amanda Aerni,

Daniel Coluccia,

Jürgen Hänggi,

Christian R.A. Mondadori,

Andreas Buchmann,

Eric M. Reiman,

Richard J. Caselli,

Katharina Henke,

Dominique J.F. de Quervain

Publication year - 2006

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1129837

Subject(s) - allele , locus (genetics) , episodic memory , functional magnetic resonance imaging , genetics , gene , trait , biology , expression quantitative trait loci , neuroscience , cognition , computer science , genotype , programming language , single nucleotide polymorphism

Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research