RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila | Zendy

Xiaohong Wang | Zendy; Roghiyh Aliyari | Zendy; Wan-Xiang Li | Zendy; Hong-Wei Li | Zendy; Kevin Kim | Zendy; Richard W. Carthew | Zendy; Peter W. Atkinson | Zendy; ShouWei Ding | Zendy

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RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila

Author(s) -

Xiaohong Wang,

Roghiyh Aliyari,

Wan-Xiang Li,

Hong-Wei Li,

Kevin Kim,

Richard W. Carthew,

Peter W. Atkinson,

ShouWei Ding

Publication year - 2006

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1125694

Subject(s) - innate immune system , rna interference , drosophila (subgenus) , biology , immunity , rna , virology , intrinsic immunity , microbiology and biotechnology , genetics , gene , immune system

Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.

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