Early Asymmetry of Gene Transcription in Embryonic Human Left and Right Cerebral Cortex | Zendy

Tao Sun | Zendy; Christina Patoine | Zendy; Amir AbuKhalil | Zendy; Jane E. Visvader | Zendy; Eleanor Y. M. Sum | Zendy; Timothy J. Cherry | Zendy; Stuart H. Orkin | Zendy; Daniel H. Geschwind | Zendy; Christopher A. Walsh | Zendy

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Early Asymmetry of Gene Transcription in Embryonic Human Left and Right Cerebral Cortex

Author(s) -

Tao Sun,

Christina Patoine,

Amir AbuKhalil,

Jane E. Visvader,

Eleanor Y. M. Sum,

Timothy J. Cherry,

Stuart H. Orkin,

Daniel H. Geschwind,

Christopher A. Walsh

Publication year - 2005

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1110324

Subject(s) - cerebral cortex , brain asymmetry , biology , human brain , cortex (anatomy) , neuroscience , gene expression , embryonic stem cell , anatomy , gene , asymmetry , lateralization of brain function , genetics , physics , quantum mechanics

The human left and right cerebral hemispheres are anatomically and functionally asymmetric. To test whether human cortical asymmetry has a molecular basis, we studied gene expression levels between the left and right embryonic hemispheres using serial analysis of gene expression (SAGE). We identified and verified 27 differentially expressed genes, which suggests that human cortical asymmetry is accompanied by early, marked transcriptional asymmetries. LMO4 is consistently more highly expressed in the right perisylvian human cerebral cortex than in the left and is essential for cortical development in mice, suggesting that human left-right specialization reflects asymmetric cortical development at early stages.

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