The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans | Zendy

Brendan Loftus | Zendy; Eula Fung | Zendy; Paola Roncaglia | Zendy; Don Rowley | Zendy; Paolo Amedeo | Zendy; Dan Bruno | Zendy; Jessica Vamathevan | Zendy; Molly Miranda | Zendy; Iain Anderson | Zendy; James A. Fraser | Zendy; Jonathan Allen | Zendy; Ian E. Bosdet | Zendy; Michael R. Brent | Zendy; Readman Chiu | Zendy; Tamara L. Doering | Zendy; Maureen J. Donlin | Zendy; Cletus A. D’Souza | Zendy; Deborah S. Fox | Zendy; V.B. Grinberg | Zendy; Jianmin Fu | Zendy; Marilyn Fukushima | Zendy; Brian J. Haas | Zendy; James Huang | Zendy; Guilhem Janbon | Zendy; Steven J.M. Jones | Zendy; Hean Koo | Zendy; Martin Krzywinski | Zendy; June K. Kwon-Chung | Zendy; Klaus B. Lengeler | Zendy; Rama Maiti | Zendy; Marco A. Marra | Zendy; Robert E. Marra | Zendy; Carrie Mathewson | Zendy; Thomas G. Mitchell | Zendy; Mihaela Pertea | Zendy; Florenta Riggs | Zendy; Steven L. Salzberg | Zendy; Jacqueline E. Schein | Zendy; Alla Shvartsbeyn | Zendy; Heesun Shin | Zendy; Martin Shumway | Zendy; Charles A. Specht | Zendy; Bernard Suh | Zendy; Aaron Tenney | Zendy; Terry Utterback | Zendy; Brian L. Wickes | Zendy; Jennifer R. Wortman | Zendy; Natasja H. Wye | Zendy; James W. Kronstad | Zendy; Jennifer K. Lodge | Zendy; Joseph Heitman | Zendy; Ronald W. Davis | Zendy; Claire M. Fraser | Zendy; Richard W. Hyman | Zendy

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The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans

Author(s) -

Brendan Loftus,

Eula Fung,

Paola Roncaglia,

Don Rowley,

Paolo Amedeo,

Dan Bruno,

Jessica Vamathevan,

Molly Miranda,

Iain Anderson,

James A. Fraser,

Jonathan Allen,

Ian E. Bosdet,

Michael R. Brent,

Readman Chiu,

Tamara L. Doering,

Maureen J. Donlin,

Cletus A. D’Souza,

Deborah S. Fox,

V.B. Grinberg,

Jianmin Fu,

Marilyn Fukushima,

Brian J. Haas,

James Huang,

Guilhem Janbon,

Steven J.M. Jones,

Hean Koo,

Martin Krzywinski,

June K. Kwon-Chung,

Klaus B. Lengeler,

Rama Maiti,

Marco A. Marra,

Robert E. Marra,

Carrie Mathewson,

Thomas G. Mitchell,

Mihaela Pertea,

Florenta Riggs,

Steven L. Salzberg,

Jacqueline E. Schein,

Alla Shvartsbeyn,

Heesun Shin,

Martin Shumway,

Charles A. Specht,

Bernard Suh,

Aaron Tenney,

Terry Utterback,

Brian L. Wickes,

Jennifer R. Wortman,

Natasja H. Wye,

James W. Kronstad,

Jennifer K. Lodge,

Joseph Heitman,

Ronald W. Davis,

Claire M. Fraser,

Richard W. Hyman

Publication year - 2005

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1103773

Subject(s) - cryptococcus neoformans , biology , genome , transposable element , gene , genetics , transcriptome , virulence , whole genome sequencing , gene expression

Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its approximately 20-megabase genome, which contains approximately 6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.

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