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As a result of the differential (intrasynaptic versus extrasynaptic) localization and agonist affinity of NR2A-containing and NR2B-containing N -methyl-d-aspartate receptors (NMDARs), Rusakov et al . ([ 1 ][1]) propose that the production of long-term potentiation (LTP) versus long-term depression (

Response to Comment on "Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity"