Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic | Zendy

Marcel Leist | Zendy; Pietro Ghezzi | Zendy; Giovanni Grasso | Zendy; Roberto Bianchi | Zendy; Pia Villa | Zendy; Maddalena Fratelli | Zendy; Costanza Savino | Zendy; Marina Bianchi | Zendy; Jacob Nielsen | Zendy; Jens Gerwien | Zendy; Pekka Kallunki | Zendy; Anna Kirstine Larsen | Zendy; Lone Helboe | Zendy; Søren Christensen | Zendy; Lars Østergaard Pedersen | Zendy; Mette Nielsen | Zendy; Lars Torup | Zendy; Thomas N. Sager | Zendy; Alessandra Sfacteria | Zendy; Serhat Erbayraktar | Zendy; Zübeyde Erbayraktar | Zendy; Necati Gökmen | Zendy; Osman Yılmaz | Zendy; Anthony Cerami | Zendy; Q W Xie | Zendy; Thomas R. Coleman | Zendy; Michael Brines | Zendy

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Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic

Author(s) -

Marcel Leist,

Pietro Ghezzi,

Giovanni Grasso,

Roberto Bianchi,

Pia Villa,

Maddalena Fratelli,

Costanza Savino,

Marina Bianchi,

Jacob Nielsen,

Jens Gerwien,

Pekka Kallunki,

Anna Kirstine Larsen,

Lone Helboe,

Søren Christensen,

Lars Østergaard Pedersen,

Mette Nielsen,

Lars Torup,

Thomas N. Sager,

Alessandra Sfacteria,

Serhat Erbayraktar,

Zübeyde Erbayraktar,

Necati Gökmen,

Osman Yılmaz,

Anthony Cerami,

Q W Xie,

Thomas R. Coleman,

Michael Brines

Publication year - 2004

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1098313

Subject(s) - erythropoietin , erythropoietin receptor , haematopoiesis , neuroprotection , receptor , pharmacology , experimental autoimmune encephalomyelitis , chemistry , biology , immunology , central nervous system , endocrinology , medicine , microbiology and biotechnology , stem cell

Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype-selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutants did not bind to the classical EPO receptor (EPOR) and did not show any hematopoietic activity in human cell signaling assays or upon chronic dosing in different animal species. Nevertheless, CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyelitis at a potency and efficacy comparable to EPO.

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