Cognitive Inflexibility After Prefrontal Serotonin Depletion | Zendy

Hannah F. Clarke | Zendy; Jeffrey W. Dalley | Zendy; H. S. Crofts | Zendy; Trevor W. Robbins | Zendy; Angela Roberts | Zendy

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Cognitive Inflexibility After Prefrontal Serotonin Depletion

Author(s) -

Hannah F. Clarke,

Jeffrey W. Dalley,

H. S. Crofts,

Trevor W. Robbins,

Angela Roberts

Publication year - 2004

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1094987

Subject(s) - perseveration , cognitive flexibility , prefrontal cortex , serotonergic , neuroscience , serotonin , marmoset , psychology , cognition , stimulus (psychology) , cognitive psychology , medicine , biology , paleontology , receptor

Serotonergic dysregulation within the prefrontal cortex (PFC) is implicated in many neuropsychiatric disorders, but the precise role of serotonin within the PFC is poorly understood. Using a serial discrimination reversal paradigm, we showed that upon reversal, selective serotonin depletion of the marmoset PFC produced perseverative responding to the previously rewarded stimulus without any significant effects on either retention of a discrimination learned preoperatively or acquisition of a novel discrimination postoperatively. These results highlight the importance of prefrontal serotonin in behavioral flexibility and are highly relevant to obsessive-compulsive disorder, schizophrenia, and the cognitive sequelae of drug abuse in which perseveration is prominent.

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