Cdh1-APC Controls Axonal Growth and Patterning in the Mammalian Brain | Zendy

Yoshiyuki Konishi | Zendy; Judith Stegmüller | Zendy; Takahiko Matsuda | Zendy; Shirin Bonni | Zendy; Azad Bonni | Zendy

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Cdh1-APC Controls Axonal Growth and Patterning in the Mammalian Brain

Author(s) -

Yoshiyuki Konishi,

Judith Stegmüller,

Takahiko Matsuda,

Shirin Bonni,

Azad Bonni

Publication year - 2004

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1093712

Subject(s) - cdh1 , biology , neuroscience , growth cone , neurite , microbiology and biotechnology , cerebellum , neuron , myelin , gene knockdown , rna interference , inhibitory postsynaptic potential , axon , central nervous system , cell , cadherin , rna , cell culture , in vitro , genetics , gene

The anaphase-promoting complex (APC) is highly expressed in postmitotic neurons, but its function in the nervous system was previously unknown. We report that the inhibition of Cdh1-APC in primary neurons specifically enhanced axonal growth. Cdh1 knockdown in cerebellar slice overlay assays and in the developing rat cerebellum in vivo revealed cell-autonomous abnormalities in layer-specific growth of granule neuron axons and parallel fiber patterning. Cdh1 RNA interference in neurons was also found to override the inhibitory influence of myelin on axonal growth. Thus, Cdh1-APC appears to play a role in regulating axonal growth and patterning in the developing brain that may also limit the growth of injured axons in the adult brain.

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