A Map of the Interactome Network of the Metazoan C. elegans | Zendy

Siming Li | Zendy; Christopher M. Armstrong | Zendy; Nicolas Bertin | Zendy; Hui Ming Ge | Zendy; Stuart Milstein | Zendy; Mike Boxem | Zendy; PierreOlivier Vidalain | Zendy; Jing-Dong Han | Zendy; Alban Chesneau | Zendy; Tong Hao | Zendy; Debra S. Goldberg | Zendy; Ning Li | Zendy; Monica Martinez | Zendy; JeanFrançois Rual | Zendy; Philippe Lamesch | Zendy; Lai Xu | Zendy; Muneesh Tewari | Zendy; S. L. Wong | Zendy; Lan V. Zhang | Zendy; Gabriel F. Berriz | Zendy; Laurent Jacotot | Zendy; Philippe Vaglio | Zendy; Jérôme Reboul | Zendy; Tomoko Hirozane-Kishikawa | Zendy; Qianru Li | Zendy; Harrison W. Gabel | Zendy; Ahmed Elewa | Zendy; Bridget Baumgartner | Zendy; Debra J. Rose | Zendy; Haiyuan Yu | Zendy; Stephanie Bosak | Zendy; Reynaldo Sequerra | Zendy; Andrew Fraser | Zendy; Susan E. Mango | Zendy; William M. Saxton | Zendy; Susan Strome | Zendy; Sander van den Heuvel | Zendy; Fabio Piano | Zendy; Jean Vandenhaute | Zendy; Claude Sardet | Zendy; Mark Gerstein | Zendy; Lynn DoucetteStamm | Zendy; Kristin C. Gunsalus | Zendy; J. Wade Harper | Zendy; M. E. Cusick | Zendy; Frederick P. Roth | Zendy; David E. Hill | Zendy; Marc Vidal | Zendy

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A Map of the Interactome Network of the Metazoan C. elegans

Author(s) -

Siming Li,

Christopher M. Armstrong,

Nicolas Bertin,

Hui Ming Ge,

Stuart Milstein,

Mike Boxem,

PierreOlivier Vidalain,

Jing-Dong Han,

Alban Chesneau,

Tong Hao,

Debra S. Goldberg,

Ning Li,

Monica Martinez,

JeanFrançois Rual,

Philippe Lamesch,

Lai Xu,

Muneesh Tewari,

S. L. Wong,

Lan V. Zhang,

Gabriel F. Berriz,

Laurent Jacotot,

Philippe Vaglio,

Jérôme Reboul,

Tomoko Hirozane-Kishikawa,

Qianru Li,

Harrison W. Gabel,

Ahmed Elewa,

Bridget Baumgartner,

Debra J. Rose,

Haiyuan Yu,

Stephanie Bosak,

Reynaldo Sequerra,

Andrew Fraser,

Susan E. Mango,

William M. Saxton,

Susan Strome,

Sander van den Heuvel,

Fabio Piano,

Jean Vandenhaute,

Claude Sardet,

Mark Gerstein,

Lynn DoucetteStamm,

Kristin C. Gunsalus,

J. Wade Harper,

M. E. Cusick,

Frederick P. Roth,

David E. Hill,

Marc Vidal

Publication year - 2004

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1091403

Subject(s) - interactome , in silico , phenome , computational biology , biology , biological network , multicellular organism , interaction network , systems biology , caenorhabditis elegans , transcriptome , computer science , gene , genetics , genome , gene expression

To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally validated the overall quality of this Y2H data set. Together with already described Y2H interactions and interologs predicted in silico, the current version of the Worm Interactome (WI5) map contains approximately 5500 interactions. Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses.

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