Asymmetrical Allocation of NMDA Receptor ε2 Subunits in Hippocampal Circuitry | Zendy

Ryosuke Kawakami | Zendy; Yoshiaki Shinohara | Zendy; Yuichiro K. Kato | Zendy; Hiroyuki Sugiyama | Zendy; Ryuichi Shigemoto | Zendy; Isao Ito | Zendy

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Asymmetrical Allocation of NMDA Receptor ε2 Subunits in Hippocampal Circuitry

Author(s) -

Ryosuke Kawakami,

Yoshiaki Shinohara,

Yuichiro K. Kato,

Hiroyuki Sugiyama,

Ryuichi Shigemoto,

Isao Ito

Publication year - 2003

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1082609

Subject(s) - nmda receptor , neuroscience , hippocampal formation , hippocampus , synaptic plasticity , protein subunit , neuroplasticity , biology , receptor , biochemistry , gene

Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRepsilon2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of epsilon2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain.

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