Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates | Zendy

Xuetong Shen | Zendy; Hua Xiao | Zendy; Ryan T. Ranallo | Zendy; Wei-Hua Wu | Zendy; Carl Wu | Zendy

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Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates

Author(s) -

Xuetong Shen,

Hua Xiao,

Ryan T. Ranallo,

Wei-Hua Wu,

Carl Wu

Publication year - 2003

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1078068

Subject(s) - inositol , nucleosome , chromatin , chromatin remodeling , swi/snf , microbiology and biotechnology , inositol trisphosphate receptor , biology , polyphosphate , inositol phosphate , gene expression , biochemistry , transcription factor , kinase , regulation of gene expression , transcription (linguistics) , chemistry , gene , receptor , linguistics , philosophy , phosphate

Eukaryotes use adenosine triphosphate (ATP)-dependent chromatin-remodeling complexes to regulate gene expression. Here, we show that inositol polyphosphates can modulate the activities of several chromatin-remodeling complexes in vitro. Inositol hexakisphosphate (IP6) inhibits nucleosome mobilization by NURF, ISW2, and INO80 complexes. In contrast, nucleosome mobilization by the yeast SWI/SNF complex is stimulated by inositol tetrakisphosphate (IP4) and inositol pentakisphosphate (IP5). We demonstrate that mutations in genes encoding inositol polyphosphate kinases that produce IP4, IP5, and IP6 impair transcription in vivo. These results provide a link between inositol polyphosphates, chromatin remodeling, and gene expression.

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