Regulation of Chromatin Remodeling by Inositol Polyphosphates | Zendy

David J. Steger | Zendy; Elizabeth S. Haswell | Zendy; Aimee L. Miller | Zendy; Susan R. Wente | Zendy; Erin K. O’Shea | Zendy

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Regulation of Chromatin Remodeling by Inositol Polyphosphates

Author(s) -

David J. Steger,

Elizabeth S. Haswell,

Aimee L. Miller,

Susan R. Wente,

Erin K. O’Shea

Publication year - 2003

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1078062

Subject(s) - chromatin remodeling , chromatin , swi/snf , microbiology and biotechnology , biology , chromatin structure remodeling (rsc) complex , transcription (linguistics) , mutant , inositol , promoter , gene , biochemistry , gene expression , linguistics , philosophy , receptor

Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5 gene, we identified mutations in ARG82/IPK2, which encodes a nuclear inositol polyphosphate kinase. In arg82 mutant strains, remodeling of PHO5 promoter chromatin is impaired, and the adenosine triphosphate-dependent chromatin-remodeling complexes SWI/SNF and INO80 are not efficiently recruited to phosphate-responsive promoters. These results suggest a role for the small molecule inositol polyphosphate in the regulation of chromatin remodeling and transcription.

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