Role of Toxoplasma gondii Myosin A in Powering Parasite Gliding and Host Cell Invasion | Zendy

Markus Meissner | Zendy; Dirk Schlüter | Zendy; Dominique SoldatiFavre | Zendy

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Role of Toxoplasma gondii Myosin A in Powering Parasite Gliding and Host Cell Invasion

Author(s) -

Markus Meissner,

Dirk Schlüter,

Dominique SoldatiFavre

Publication year - 2002

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1074553

Subject(s) - myosin , toxoplasma gondii , biology , obligate , intracellular parasite , microbiology and biotechnology , host (biology) , intracellular , transactivation , molecular motor , parasite hosting , apicomplexa , gene , genetics , gene expression , immunology , ecology , world wide web , computer science , malaria , antibody , plasmodium falciparum

Obligate intracellular apicomplexan parasites rely on gliding motion powered by their actomyosin system to disperse throughout tissues and to penetrate host cells. Toxoplasma gondii myosin A has been implicated in this process, but direct proof has been lacking. We designed a genetic screen to generate a tetracycline-inducible transactivator system in T. gondii. The MyoA gene was disrupted in the presence of a second regulatable copy of MyoA. Conditional removal of this myosin caused severe impairment in host cell invasion and parasite spreading in cultured cells, and unambiguously established the pathogenic function of this motor in an animal model.

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