Open AccessDecoding the Patterns of Self and Nonself by the Innate Immune System
Author(s) -
Ruslan Medzhitov,
Charles A. Janeway
Publication year - 2002
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.1068883
Subject(s) - innate immune system , immune system , biology , pattern recognition receptor , immunology , decoding methods , receptor , computer science , genetics , telecommunications
The innate immune system evolved several strategies of self/nonself discrimination that are based on the recognition of molecular patterns demarcating infectious nonself, as well as normal and abnormal self. These patterns are deciphered by receptors that either induce or inhibit an immune response, depending on the meaning of these signals.
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