Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans | Zendy

Peter Baumann | Zendy; Thomas R. Cech | Zendy

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Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans

Author(s) -

Peter Baumann,

Thomas R. Cech

Publication year - 2001

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1060036

Subject(s) - telomere , biology , telomere binding protein , genetics , homologous chromosome , chromosome , yeast , dna , schizosaccharomyces pombe , gene , eukaryotic chromosome fine structure , microbiology and biotechnology , dna binding protein , saccharomyces cerevisiae , transcription factor

Telomere proteins from ciliated protozoa bind to the single-stranded G-rich DNA extensions at the ends of macronuclear chromosomes. We have now identified homologous proteins in fission yeast and in humans. These Pot1 (protection of telomeres) proteins each bind the G-rich strand of their own telomeric repeat sequence, consistent with a direct role in protecting chromosome ends. Deletion of the fission yeast pot1+ gene has an immediate effect on chromosome stability, causing rapid loss of telomeric DNA and chromosome circularization. It now appears that the protein that caps the ends of chromosomes is widely dispersed throughout the eukaryotic kingdom.

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