Open AccessA genome-engineered bioartificial implant for autoregulated anticytokine drug delivery
Author(s) -
YunRak Choi,
Kelsey H. Collins,
Luke E. Springer,
Lara Pferdehirt,
Alison K. Ross,
ChiaLung Wu,
Franklin T. Moutos,
Natalia S. Harasymowicz,
Jonathan M. Brunger,
Christine T. N. Pham,
Farshid Guilak
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abj1414
Subject(s) - implant , inflammation , arthritis , medicine , drug delivery , drug , genome , pharmacology , biology , immunology , materials science , surgery , gene , nanotechnology , genetics
Genome editing of stem cells creates a living implant that can produce arthritis-fighting drugs in response to inflammation.
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