Open AccessSTAT1 maintains naïve CD8 + T cell quiescence by suppressing the type I IFN-STAT4-mTORC1 signaling axis
Author(s) -
Yoon-Chul Kye,
Gil-Woo Lee,
Sungwoo Lee,
Young-Jun Ju,
Hee-Ok Kim,
CheolHeui Yun,
Jae-Ho Cho
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abg8764
Subject(s) - microbiology and biotechnology , biology , stat1 , cd8 , t cell , homeostasis , stat4 , mtorc1 , cd28 , interferon , signal transduction , cytotoxic t cell , immunology , immune system , stat , biochemistry , in vitro , stat3 , pi3k/akt/mtor pathway
STAT1 serves as a gatekeeper for naïve CD8+ T cell homeostasis by restraining type I IFN-STAT4-mTOR signaling axis.
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