Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression | Zendy

Ke Zhang | Zendy; Lisa Miorin | Zendy; Tadashi Makio | Zendy; Ishmael Dehghan | Zendy; Shengyan Gao | Zendy; Yihu Xie | Zendy; Hualin Zhong | Zendy; Matthew A. Esparza | Zendy; Thomas Kehrer | Zendy; Anil Kumar | Zendy; Tom C. Hobman | Zendy; Christopher P. Ptak | Zendy; Boning Gao | Zendy; John D. Minna | Zendy; Zhijian J. Chen | Zendy; Adolfo Garcı́a-Sastre | Zendy; Yi Ren | Zendy; Richard W. Wozniak | Zendy; Beatriz M. A. Fontoura | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

Author(s) -

Ke Zhang,

Lisa Miorin,

Tadashi Makio,

Ishmael Dehghan,

Shengyan Gao,

Yihu Xie,

Hualin Zhong,

Matthew A. Esparza,

Thomas Kehrer,

Anil Kumar,

Tom C. Hobman,

Christopher P. Ptak,

Boning Gao,

John D. Minna,

Zhijian J. Chen,

Adolfo Garcı́a-Sastre,

Yi Ren,

Richard W. Wozniak,

Beatriz M. A. Fontoura

Publication year - 2021

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.abe7386

Subject(s) - messenger rna , gene , gene expression , host (biology) , microbiology and biotechnology , covid-19 , biology , virology , genetics , medicine , disease , pathology , infectious disease (medical specialty)

The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted the need for understanding viral-host interactions involved in mechanisms of virulence. Here, we show that the virulence factor Nsp1 protein of SARS-CoV-2 interacts with the host messenger RNA (mRNA) export receptor heterodimer NXF1-NXT1, which is responsible for nuclear export of cellular mRNAs. Nsp1 prevents proper binding of NXF1 to mRNA export adaptors and NXF1 docking at the nuclear pore complex. As a result, a significant number of cellular mRNAs are retained in the nucleus during infection. Increased levels of NXF1 rescues the Nsp1-mediated mRNA export block and inhibits SARS-CoV-2 infection. Thus, antagonizing the Nsp1 inhibitory function on mRNA export may represent a strategy to restoring proper antiviral host gene expression in infected cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research