Open AccessTwofold improved tumor-to-brain contrast using a novel T1 relaxation-enhanced steady-state (T 1 RESS) MRI technique
Author(s) -
Robert R. Edelman,
das Leloudas,
Jianing Pang,
Julian E. Bailes,
Ryan Merrell,
Ioannis Koktzoglou
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abd1635
Subject(s) - magnetic resonance imaging , relaxation (psychology) , weighting , contrast (vision) , computer science , signal (programming language) , t2 relaxation , signal to noise ratio (imaging) , nuclear magnetic resonance , pulse sequence , biomedical engineering , pulse (music) , feature (linguistics) , materials science , physics , artificial intelligence , radiology , medicine , detector , telecommunications , linguistics , philosophy , programming language
A technique that provides more accurate cancer detection would be of great value. Toward this end, we developed T1 relaxation-enhanced steady-state (T 1 RESS), a novel magnetic resonance imaging (MRI) pulse sequence that enables the flexible modulation of T1 weighting and provides the unique feature that intravascular signals can be toggled on and off in contrast-enhanced scans. T 1 RESS makes it possible to effectively use an MRI technique with improved signal-to-noise ratio efficiency for cancer imaging. In a proof-of-concept study, "dark blood" unbalanced T 1 RESS provided a twofold improvement in tumor-to-brain contrast compared with standard techniques, whereas balanced T 1 RESS greatly enhanced vascular detail. In conclusion, T 1 RESS represents a new MRI technique with substantial potential value for cancer imaging, along with a broad range of other clinical applications.
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