The NEMP family supports metazoan fertility and nuclear envelope stiffness | Zendy

Yonit Tsatskis | Zendy; Robyn Rosenfeld | Zendy; Joel D. Pearson | Zendy; Curtis W. Boswell | Zendy; Yi Qu | Zendy; Kyunga Kim | Zendy; Lacramioara Fabian | Zendy; Ariz Mohammad | Zendy; Xian Wang | Zendy; Michael I. Robson | Zendy; Karen Krchma | Zendy; Jun Wu | Zendy; João Gonçalves | Zendy; Didier Hodzic | Zendy; ShuHsing Wu | Zendy; Daniel Potter | Zendy; Laurence Pelletier | Zendy; Wade H. Dunham | Zendy; AnneClaude Gingras | Zendy; Yu Sun | Zendy; Meng Jin | Zendy; Dorothea Godt | Zendy; Tim Schedl | Zendy; Brian Ciruna | Zendy; Kyunghee Choi | Zendy; John R. B. Perry | Zendy; Rod Bremner | Zendy; Eric C. Schirmer | Zendy; Julie A. Brill | Zendy; Andrea Jurisicova | Zendy; Helen McNeill | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The NEMP family supports metazoan fertility and nuclear envelope stiffness

Author(s) -

Yonit Tsatskis,

Robyn Rosenfeld,

Joel D. Pearson,

Curtis W. Boswell,

Yi Qu,

Kyunga Kim,

Lacramioara Fabian,

Ariz Mohammad,

Xian Wang,

Michael I. Robson,

Karen Krchma,

Jun Wu,

João Gonçalves,

Didier Hodzic,

ShuHsing Wu,

Daniel Potter,

Laurence Pelletier,

Wade H. Dunham,

AnneClaude Gingras,

Yu Sun,

Meng Jin,

Dorothea Godt,

Tim Schedl,

Brian Ciruna,

Kyunghee Choi,

John R. B. Perry,

Rod Bremner,

Eric C. Schirmer,

Julie A. Brill,

Andrea Jurisicova,

Helen McNeill

Publication year - 2020

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.abb4591

Subject(s) - softening , envelope (radar) , fertility , stiffness , computer science , biology , medicine , materials science , structural engineering , engineering , telecommunications , composite material , population , environmental health , radar

Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in () with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in , , zebrafish, and mice leads to sterility or early loss of fertility. Loss of Nemp leads to nuclear shaping defects, most prominently in the germ line. Biochemical, biophysical, and genetic studies reveal that NEMP proteins support the mechanical stiffness of the germline nuclear envelope via formation of a NEMP-EMERIN complex. These data indicate that the germline nuclear envelope has specialized mechanical properties and that NEMP proteins play essential and conserved roles in fertility.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research