Open AccessThree-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion
Author(s) -
Gustavo A. Ruiz Buendía,
Marion Leleu,
Flavia Marzetta,
Ludovica Vanzan,
Jennifer Y. Tan,
Victor Ythier,
Emma Randall,
Ana Claudia Marques,
Tuncay Baubec,
Rabih Murr,
Ioannis Xénarios,
Vincent Dion
Publication year - 2020
Publication title -
science advances
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aaz4012
Subject(s) - chromatin , trinucleotide repeat expansion , myotonic dystrophy , biology , genetics , ctcf , dna methylation , allele , gene , gene expression , enhancer
Unexpectedly, the molecular pathogenesis of expanded CAG/CTG diseases does not include changes in 3D chromatin conformation.
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