Open AccessStructure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity
Author(s) -
Tao Ni,
Fang Jiao,
Xiulian Yu,
Saša Aden,
Lucy Ginger,
Sophie I. Williams,
Fangfang Bai,
Vojtěch Pražák,
Dimple Karia,
Phillip J. Stansfeld,
Peijun Zhang,
George P. Munson,
Gregor Anderluh,
Simon Scheuring,
Robert J. C. Gilbert
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aax8286
Subject(s) - perforin , innate immune system , mechanism (biology) , immunity , microbiology and biotechnology , chemistry , biology , immunology , immune system , physics , cd8 , quantum mechanics
Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack.
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