Open AccessThe ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia
Author(s) -
John M. Muriuki,
Alexander J. Mentzer,
Gavin Band,
James J. Gilchrist,
Tommy Carstensen,
Swaib A. Lule,
Morgan M. Goheen,
Fatou Joof,
Wandia Kimita,
Reagan M. Mogire,
Clare Cutland,
Amidou Diarra,
Anna Rautanen,
Cristina Pomilla,
Deepti Gurdasani,
Kirk A. Rockett,
Neema Mturi,
Francis M. Ndungu,
J. Anthony G. Scott,
Sodiomon B. Sirima,
Alireza Morovat,
Andrew M. Prentice,
Shabir A. Madhi,
Emily L. Webb,
Alison M. Elliott,
Philip Bejon,
Manjinder S. Sandhu,
Adrian V. S. Hill,
Dominic Kwiatkowski,
Thomas N. Williams,
Anthony Cerami,
Sarah H. Atkinson
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aaw0109
Subject(s) - malaria , ferroportin , hemolysis , anemia , biology , mutation , immunology , hemolytic anemia , hepcidin , medicine , virology , genetics , gene
The FPN Q248H mutation protects children from anemia, hemolysis, and iron deficiency, but not malaria or bacterial infection.
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