Open AccessMolecular insights into the surface-catalyzed secondary nucleation of amyloid-β 40 (Aβ 40 ) by the peptide fragment Aβ 16–22
Author(s) -
Samuel J. Bunce,
Yiming Wang,
Katie L. Stewart,
Alison E. Ashcroft,
Sheena E. Radford,
Carol K. Hall,
Andrew J. Wilson
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aav8216
Subject(s) - nucleation , amyloid (mycology) , fragment (logic) , peptide , biophysics , mechanism (biology) , materials science , chemistry , biochemistry , biology , computer science , physics , organic chemistry , inorganic chemistry , programming language , quantum mechanics
Combined experiment and simulation reveals a structural mechanism of surface-catalyzed nucleation in Aβ amyloid formation.
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